A recent study published in Cell Research reported the first monkey model for mitochondrial replacement by first polar body transfer. The study was conducted by a team led by SUN Qiang and LIU Zhen. This work is the first to demonstrate the effectiveness and safety of polar body replacement at the individual primate level, and has important reference significance for the treatment of mitochondrial genetic diseases and infertility caused by low ovarian reserve.
A recent study published in Journal of Cell Biology systematically analyzed the lineage progression in zebrafish retina and provided a proof-of-concept method to get specific neuron types through lineage-dependent reprogramming. This work was conducted by researchers from Dr. HE Jie’s Lab.
A recent study published in Neuron reveals the long-range circuit underlying nociceptive information processing. This work was performed by researchers in Dr. SUN Yangang’s Lab. The results demonstrate that the ipsilateral spino-parabrachial pathway directly relay pain signals from the spinal cord to the ILN but not the amygdala, providing crucial insight into the cellular and circuitry mechanism underlying nociceptive information processing.
A recent study published in eLife reveals that the secondary motor cortex contributes to adaptive action selection during flexible visual categorization. This work was performed by researchers in Dr. YAO Haishan’s Lab. Dr. YAO’s lab demonstrates that M2 plays an important role in sensory-history-dependent adaptive choice behavior during flexible stimulus categorization.
A recent study published in American Journal of Psychiatry reported a novel cross-species translational approach for diagnostic classification in human mental disorders. This work was performed by researchers in Dr. WANG Zheng’s Lab, in close collaboration with Dr. HE Ran’s group .
Two recent research articles revealed a considerable degree of plasticity of retinal function during the early stage of development. The research was completed by Dr. ZHANG Yifeng’s lab.The research results provide a basis for exploring how environmental stimuli change the retinal circuits, and help to explore the use of early sensory experience training for adjuvant treatment of some sensory system diseases.
A recent study published in eLife reveals the different neural mechanisms underlying opioid analgesia. This study was performed by researchers in Dr. SUN Yan-Gang’s Lab.Using a combination of genetic, pharmacological, and behavioral approaches, the authors reveal that analgesic effects of exogenous and endogenous opioids on inflammatory pain are mediated by mu opioid receptors (MORs) expressed in glutamatergic and GABAergic neurons, respectively.
A recent study published in Nature Communications reveals that the top-down projection from orbitofrontal cortex to primary visual cortex contributes to visual associative learning. This work was performed by researchers in Dr. YAO Haishan’s Lab. They demonstrates that the OFC projection to V1 plays a key role in filtering out non-relevant visual information to facilitate associative learning.
A recent study published in Cell Reports demonstrates that retinoid X receptor α (Rxra) regulates docosahexaenoic acid (DHA)-dependent spinogenesis and functional synapse formation in vivo. This work was performed by researchers in Dr. YU Xiang’s Laboratory.
On May 18th, a research article named ”A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects” was published in Nature Methods, which was cooperatively accomplished by YANG Hui’s group, Li Yixue’s group and Zuo Erwei’s group.
A recent study published in Nature Communications demonstrated that spider venom-derived peptide HpTx1 induces hyperalgesia in Nav1.7 knockout mice. This finding is from a joint work by Prof. LIU Zhonghua’s team and Dr. LIU Jing Yu’s lab.
A recent study published in Cell reports demonstrates that cortical inputs from posterior amygdala (PA) onto the ventrolateral part of ventromedial hypothalamus (VMHvl) bidirectionally modulate male aggression behavior in mice. This work was performed by researchers in Dr. XU Xiao-Hong’s Lab.
A recent study published in Science Advances reports a highly sensitive and selective potassium ion (K+) nanosensor that can be excited by near-infrared (NIR) light. This work was performed by researchers in Dr. DU Jiulin’s, Dr. XIONG Zhiqi’s Labs and Dr. BU Wenbo’s Labs.
Recently, collaboration between Dr. DUAN Xiaojie’s group and Dr. LIANG Zhifeng’s group , has led to a novel MRI compatible, graphene fiber DBS electrode. Using a Parkinsonian rat model, this novel electrode achieved full activation pattern mapping by simultaneous deep brain stimulation and fMRI, and revealed close relationship between fMRI activation and DBS therapeutic improvement.
A recent study published in Journal of the American Chemical Society reports a near-infrared (NIR) voltage nanosensor that enables real-time imaging of neuronal activities in mice and zebrafish. This work was performed by researchers at Dr. DU Jiulin’s Lab.