News----Center for Excellence in Brain Science and Intelligence Technology

Engineered High-Fidelity Cas13 Variants with Minimal Collateral RNA Targeting

Novel Compact CRISPR-Cas13 Systems from Uncultivated Microbes Exhibited Robust Editing Activity for Both Mammalian and Viral RNA

Detection of Low-Abundant Transcripts and lncRNAs Using Endogeneous Promotor-Driven sgRNA

New Generation of Base Gene Editor

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Engineered High-Fidelity Cas13 Variants with Minimal Collateral RNA Targeting

Novel Compact CRISPR-Cas13 Systems from Uncultivated Microbes Exhibited Robust Editing Activity for Both Mammalian and Viral RNA

Detection of Low-Abundant Transcripts and lncRNAs Using Endogeneous Promotor-Driven sgRNA

New Generation of Base Gene Editor

Glia-to-Neuron Conversion Alleviates Symptoms of Neurological Disease in Mice

DNA Base Editing Induces Substantial Off-target RNA Mutations and Their Elimination by Mutagenesis

GOTI Makes Off-Target Nowhere to Hide

Efficient and Precise Gene Knock-in Using Tild-CRISPR in Mouse and Human Cells

Generation of Knock-In Cynomolgus Monkey Using CRISPR/Cas9-Mediated HMEJ-Based Strategy

In vivo simultaneous transcriptional activation ofmultiple genes in the brain using CRISPR–dCas9-activator transgenic mice

Targeted Chromosome Elimination by CRISPR/Cas9-Mediated Genome Editing

Generating Complete Knockout Mice and Monkey by Optimized CRISPR

Homology-Mediated End Joining-Based Strategy Showed Robust DNA Targeted Integration Efficiency both in vitro and in vivo