A research team led by WANG Zuoren in collaboration with other team has proposed a fundamentally new learning paradigm inspired by the biological brain. The findings were published in the journal Neurocomputing on December 5, 2025, under the title: “Towards Biologically Plausible DNN Optimization: Replacing Backpropagation and Loss Functions with a Top-Down Credit Assignment Network”.
On November 18, 2025, Neuroscience Bulletin published a research article titled "The Dorsal CA2 to Ventral CA1 Circuit Contributes to Spatial and Context-Dependent Memories." This insightful study, led by Dr. Chun Xu’s research group sheds new light on the hippocampal role in memory processing. Using state-of-art techniques including single-neuron projectome analysis, circuit tracing, fiber photometry recording, and optogenetics manipulation, the team revealed the critical function of the dorsal CA2 (dCA2) axon projections to ventral CA1 dorsal part (vCA1d) in spatial and context-dependent memories, offering novel perspectives on the hippocampal CA2 neurons.
In a new study, the team at Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Sciences (CAS), in collaboration with the team from the HUST-Suzhou Institute for Brainsmatics. The study reconstructed the complete axon morphologies of nearly 20,000 cortical neurons covering all brain regions of the mouse cortex, providing the largest single-neuron projectome dataset of mouse brain to date. Furthermore, this study revealed the organizing rules of cortical projection neurons in cortical connectivity and subcortical projections as well as a close relationship between intracortical connectivity, transcriptome and neuronal function through integrative analysis (Fig. 1).The team's findings were published in Neuron on November 17.
This work, led by Dr. Jiulin Du’s lab at the Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, uncovers the core regulatory mechanism of brain meningeal lymphatic system development.
