A recent study published in Nature revealed the structural basis of antidepressant ketamine action on human NMDA receptors. This work was performed by researchers in Dr. ZHU Shujia’s Lab and Dr. LUO Cheng’s team. This work has provided the structural basis of ketamine binding and action on human NMDA receptors, and paved the way for future development of ketamine-based antidepressants.
A recent study from Dr. ZHU Shujia’s Laboratory published in Neuron uncovered the gating mechanism of human GluN1-GluN2A NMDA (N-methyl-D-aspartic acid) receptor using cryo electron microscopy (Cryo-EM) and discovered a novel modulator niche resides in the linker cavity.
A recent study published in the Journal of Neuroscience demonstrated that damage to the substantia nigra (SN) correlates with basal ganglia dysfunction and poor sequencing performance in Parkinson’s disease (PD). This work was performed by researchers in Dr. YE Zheng’s Lab and Prof. JIN Lirong’s team.
A recent study published in Cell Reports demonstrated that FGF13 gene acts as an intrinsic regulator in the maintenance of the self-renewal and proliferation of NSCs in the hippocampus during the postnatal development. This work was jointly performed by Dr. ZHOU Jiawei’s Lab and Dr. HU Gang’s group.
A recent study published in Nature Communications identified a pathway from the premotor cortex to the superior colliculus that is critical during memory-guided decisions, and dissected the neural circuit mechanisms underlying motor planning. This study was conducted by Xu Ninglong’s lab.
A recent study published in Neuron unraveled the computational mechanism of a specifically defined neural circuit in the cerebral cortex underlying the rule-based flexible decision-making behavior. This work was performed by the team from Dr. XU Ninglong’s lab.
A recent study published in Nature Methods demonstrated that novel compact CRISPR-Cas13 systems identified from uncultivated microbes exhibited robust RNA interference and base editing activity for both mammalian and viral RNA in cultured cells. This work was performed by researchers in Dr. Yang Hui’s Lab and Dr. Lai Jingsheng’s team .
In a study published in eLife by Dr. GU Yong’s lab , they used a virtual reality system in conjunction with extracellular electrophysiological recording techniques in awake macaques to investigate the encoding of self-motion signals in posterior cingulate region neurons in the macaque brain, and found that posterior cingulate cortex (PCC) carries robust vestibular signals with complex temporal-spatial tuning properties.
A recent study published in Current Biology demonstrated that there is a labeled line in the mouse retina that mediates looming triggered innate defensive response. This work was performed by researchers in Dr. ZHANG Yifeng’s Lab. This work has successfully identified a molecular marker for OFF-transient alpha retinal ganglion cells (αRGCs), studied these cells’ response to looming stimuli, and connected their activity to the behavioral output triggered by looming visual stimuli.
Recently, Dr. LIU Zhiyong’s group established a rapid genetic screening method. This study highlights that mosaic CRISPR-stop is a reliable method and will pave the way for genetic screening of developmentally essential genes in the mouse inner ear and other organs.
A recent study published in Nature Cell Biology demonstrates that the low-abundant transcripts and long non-coding RNAs (lncRNAs) could successfully be detected. This study was performed by researchers in Dr. YANG Hui's team and Dr. ZHOU Haibo's team. In this research, researchers developed a highly flexible sgRNA switch (Ents) driven by an endogenous promoter, which can theoretically process the information of any endogenous transcript.
